Khawar Siddique, M.D.
Khawar Siddique, MD is a neurosurgeon who specializes in spinal disorders. He treats many conditions in the cervical, thoracic, and lumbar spine. Special interests include spinal tumors, advanced minimally invasive approaches (such as percutaneous decompressions and fusions), cervical spine deformity, Chiari decompressions, novel cervical fusion techniques, and lumbar deformity. He has experience in many new spinal procedures, including motion preservation technology (artificial disk replacements and “soft” stabilization procedures), minimally invasive decompressions and fusions, and image-guided spine surgery.
His research interests include spinal cord injury, models of spinal metastatic tumors and traumatic brain injuries. He is currently Principal Investigator at Cedars-Sinai Medical Center for the Duragen IDE trial on reduction of post-operative scarring after lumbar diskectomy.
Board eligible for the American Board of Neurological Surgery, Dr. Siddique is a member of the American Association of Neurological Surgeons, American Association for Cancer Research and Congress of Neurological Surgeons. He has written many articles and book chapters for peer-reviewed publications, including Journal of Neurosurgery, Neurosurgical Focus, Oncogene, and International Journal of Oncology. He has given many podium presentations on advanced spine surgical techniques and has taught many surgical dissection courses to other neurosurgeons and orthopedic surgeons.
Dr. Siddique graduated with a B.S. in Physiology with honors (cum laude and with Highest Distinction) from the University of Illinois at Urbana-Champaign. He earned his medical degree with Alpha Omega Alpha (AOA) Honors (ranked in the top 10% of his medical school class) from the University Of Illinois College Of Medicine. Thereafter, he completed his 6-year residency training in Neurosurgery from the University Of Illinois College Of Medicine at Peoria. Dr. Siddique then completed a 1-year fellowship in Spine Surgery at Cedars-Sinai Medical Center.
 Publications
Education
Undergraduate:Bachelor of Science in Physiology, July 1990-May 1994
University of Illinois at Urbana-Champaign
Urbana, Illinois
Medicine: Doctor of Medicine, July 1994-May 1998
University of Illinois College of Medicine
Peoria, Illinois
Post Graduate Training
General Surgery Internship, July, 1998-June, 1999
University of Illinois College of Medicine
Peoria, Illinois
Neurosurgery Residency, July, 1999-June, 2004
University of Illinois College of Medicine
Peoria, Illinois
Spinal Surgery Fellowship, July, 2004-June, 2005
Institute for Spinal Disorders
Cedars-Sinai Medical Center
Los Angeles, California
Appointments
July, 2004 to present Attending Neurosurgeon
Cedars-Sinai Medical Center
Los Angeles, California
Research Experience
Multi-center, randomized, controlled trial of Duragen Plus adhesion barrier matrix to minimize adhesions following lumbar discectomy. Principal investigator for Cedars-Sinai Medical Center site. July 2006-current.
Randomized, double blind evaluation of local anesthetic for post-operative pain after cervical spine surgery, July 2005-current
Analysis of proteases in brain tumors and spinal melanoma metastases, Department of Basic and Therapeutic Sciences, University of Illinois College of Medicine at Peoria, July, 2001-July, 2002
Pneumatic brain injury in rats, in vivo intracranial microdialysis, Traumatic brain injury, Department of Basic and Therapeutic Sciences, University of Illinois College of Medicine at Peoria, Sept., 1996–July, 1998
Neuroendocrinology, Intracranial surgery in rats, binding assays, Department of Physiology, University of Illinois, Urbana July, 1993-May, 1995
PCR techniques for gene analysis in plants, Department of Plant Biology, Univ. of Illinois, Urbana July, 1991
Honors & Awards
1990-1994 Dean’s List, University of Illinois (8 consecutive semesters)
1990-1994 Phi Eta Sigma Honor Society
Illinois State Scholar, Golden Key National Honor Society
Clarence E. Brehm Scholar, Edmund James Research Scholar
1994 Highest Distinction in Physiology, University of Illinois at Urbana
1994 Cum laude, University of Illinois at Urbana
1994 Howard Ducoff Prize for Best Senior Thesis
1998 Alpha Omega Alpha, University of Illinois College of Medicine
Professional Organizations
- American Board Neurological Surgeons, Board Eligible
- Congress of Neurological Surgeons
- American Association of Neurological Surgeons, Candidate Member
- American Association for Cancer Research
- AANS/CNS Joint Section of Spine
Accreditations
ABNS Primary Examination, 2002
California Medical Licensure (A85394)
Illinois Medical Licensure (036-105044)
Georgia Medical Licensure (055644)
ACLS/ATLS
Publications
1.Ramirez V, Zheng J, Siddique K: Membrane receptors for estrogen, progesterone, and testosterone in the rat brain: fantasy or reality. Cellular & Molecular Neurobiology. 16: 175-98, 1996 Apr.
2.Siddique K, Zagardo M, Gujrati M, Olivero W: Ganglioglioma presenting as meningioma: case report and review of the literature. Neurosurgery 50: 1133-1135, 2002 May.
3.Mohanam S. Chandrasekar N. Yanamandra N. Siddique K. Mirza F. Dinh DH. Olivero WC. Rao JS: Modulation of invasive properties of human glioblastoma cells stably expressing amino-terminal fragment of urokinase-type plasminogen activator. Oncogene. 21(51): 7824-30, 2002 Nov 7.
4.Lakka SS. Rajan M. Gondi C. Yanamandra N. Chandrasekar N. Jasti SL. Adachi Y. Siddique K. Gujrati M. Olivero W. Dinh DH. Kouraklis G. Kyritsis AP. Rao JS: Adenovirus-mediated expression of antisense MMP-9 in glioma cells inhibits tumor growth and invasion. Oncogene. 21(52): 8011-9, 2002 Nov 14.
5.Konduri SD. Yanamandra N. Siddique K. Joseph A. Dinh DH. Olivero WC. Gujrati M. Kouraklis G. Swaroop A. Kyritsis AP. Rao JS: Modulation of cystatin C expression impairs the invasive and tumorigenic potential of human glioblastoma cells. Oncogene. 21(57): 8705-12, 2002 Dec 12.
6.Siddique K. Yanamandra N. Gujrati M. Dinh D. Rao JS. Olivero W: Expression of matrix metalloproteinases, their inhibitors, and urokinase plasminogen activator in human meningiomas. International Journal of Oncology. 22(2): 289-94, 2003 Feb.
7.Gondi C, Lakka S, Yanamandra N, Siddique K, Dinh D, Olivero W, Gujrati M, Rao J: Expression of antisense uPAR and antisense uPA from a bicistronic adenoviral construct inhibits glioma cell invasion, tumor growth, and angiogenesis. Oncogene. 22: 5967-5975, 2003 Sep.
8.Siddique K, Alvernia J, Fraser K, Lanzino G: Treatment of aneurysms with wires and electricity: a historical overview. J Neurosurg 99: 1102-1107, 2003 Dec.
9.Anand N, Siddique K: Treatment Intensity Score (TIS): an objective instrument for measuring pain among spine patients. Neurosurgery. Submitted.
10.Baron E, Siddique K, Perri B, Anand N, Johnson JP. Anterior transoral resection. Operative Techniques in Orthopedics. 17: 156-162, 2007 Jul.
11.Perri B, Siddique K, Baron E, Lauryssen C. Acute odontoid fractures: anterior odontoid fixation. Operative Techniques in Orthopedics. 17: 163-168, 2007 Jul.
12.Anand N, Baron EM, Siddique K, Perri B, Bray RS. Comparison of traditional midline approach versus muscle sparring paraspinal approach for posterior non-fusion stabilization of the lumbar spine – An analysis of functional outcomes. Journal of Neurosurgery Spine 2007. Under Review
13.Mundwiler ML, Siddique K, Dym JM, Perri B, Johnson JP, Weisman MH. Complications of the spine in ankylosing spondylitis with a focus on deformity correction. Neurosurg Focus 24 (1): E6, 2008.
Book Chapters
1.Rustamzadeh E, Siddique K, Johnson JP: Fracture-dislocations of the thoraco-lumbar spine. In: Pediatric and Adult Spinal Trauma. Editors: Kim D, Ludwig S, Vaccaro A.
2.Perri B, Siddique K, Anand N, Pashman R and Johnson JP. Charité SBIII Artificial Disc Replacement: Techniques for Surgical Implantation. Instructional Video in Vaccaro, AR, Baron, EM Atlas of Spinal Surgery. Elsevier Medical Publishing, Philadelphia. 2007
3.Mathur S, Perri B, Siddique K, Shanti N, Azer E. Acute Odontoid Fractures. In press, 2007.
National Conference Presenations
1.Siddique K: Options for surgical treatment of osteomyelitis. Richard Lende Winter Neurosurgical Conference, Snowbird, Utah, Jan 29, 2005.
2.Siddique K: Indications & outcomes of lumbar disc replacement. . 5th Annual Symposium on Current Concepts in Spinal Disorders, Cedars-Sinai Institute for Spinal Disorders. Las Vegas, NV, Feb 3, 2006.
3.Siddique K: Kyhpoplasty & your surgical practice. 5th Annual Symposium on Current Concepts in Spinal Disorders, Cedars-Sinai Institute for Spinal Disorders. Las Vegas, NV, Feb 4, 2006.
4.Siddique K: Management of Atlanto-Axial instability. 33rd Annual Meeting of Caribbean Association of Neurological Surgeons. Negril, Jamaica. Nov 9, 2006.
5.Siddique K: Management issues of lumbar instability: the ALIF, PLIF, XLIF operations. 33rd Annual Meeting of Caribbean Association of Neurological Surgeons. Negril, Jamaica. Nov 10, 2006.
6.Siddique K, Ghostine S, Perri B, Johnson JP. Sacral insufficiency fractures after lumbar fusion. 33rd Annual Richard Lende Winter Neurosurgery Meeting. Snowbird, Utah. Feb 2007.
7.Siddique K: Kyphoplasty and vertebroplasty for spinal tumors. 6th Annual Symposium on Current Concepts in Spinal Disorders, Cedars-Sinai Institute for Spinal Disorders. Las Vegas, NV, Mar, 2007.
Abstracts & Posters
1.Siddique K, Ramirez V. Identification of specific membrane binding sites for testosterone in the rat brain. Argonne Symposium for Undergraduates. 5, 1993.
2.Ramirez V, Siddique K. Characterization of a membrane testosterone receptor (mTR) in the rat brain. Endocrine Society Abstracts. 489, 1994.
3.Siddique K, Brand L, Dinh D. Human cadaveric analysis of thoracic vertebra anatomy. Congress of Neurological Surgeons Annual Meeting, 2002.
4.Siddique K, Rao J, Gujrati M, Olivero W. Analysis of proteases in human brain tumors. Congress of Neurological Surgeons Annual Meeting, 2002.
5.Siddique K, Waldron K, Dinh D. Posterior rod and hook construct versus pedicle screws for thoracolumbar burst fractures. Congress of Neurological Surgeons Annual Meeting, 2002.
6.Gondi C, Lakka S, Yanamandra N, Siddique K, Gujrati M, Olivero W, Dinh D, Rao J. Regulation of glioma invasion by bicistronic antisense constructs. Society for Neuro-Oncology Seventh Annual Meeting, Nov 2002.
7.Waldron K, Siddique K, Yanamandra N, Dinh D, Olivero W, Gujrati M, Rao, J. uPA and MMP-2 are upregulated during the progression of tumor and compression of spinal cord in a mouse model of vertebral body melanoma metastasis. American Association for Cancer Research Annual Meeting, 2003.
8.Siddique K, Johnson JP. Spinal osteomyelitis: instrumentation and graft options. IMAST Annual meeting, Banff, Canada, July 2005.
9.Siddique K, Vadivelu S, Pashman, R. Symptomatic adjacent level disease (ALD) following L5-S1 anterior lumbar interbody fusion. IMAST Annual meeting, Banff, Canada, July 2005.
10.Anand N, Siddique K, Bray R. Posterior Non-Fusion Stabilization of the Lumbar Spine for Degenerative Disc Disease – Clinical, Radiological and Functional Results. IMAST Annual Meeting, Athens, Greece, July 2006.
11.Anand N, Baron E, Perri B, Siddique K, Bray RS. Comparison of traditional midline approach versus muscle splitting paraspinal approach for posterior non-fusion stabilization of the lumbar spine – An analysis of functional outcome. AANS/CNS Section on Disorders of the Spine and Peripheral Nerves. Phoenix, AZ, Mar 2007.
12.Siddique K, Vasudevan R. Ectopic Bone Formation And Osteonecrosis After Lumbar Interbody Fusion Using Recombinant Human Bone Morphogenetic Protein. AANS/CNS Section on Disorders of the Spine and Peripheral Nerves. Phoenix, AZ, Mar 2007.
Video
1.Artificial Disc Replacement: Techniques for Surgical Implantation.
Perri B, Siddique K, Anand N, Pashman RS, and Johnson JP. Charité SBIII Instructional Video in Vaccaro AR, Baron EM Atlas of Spinal Surgery. Elsevier Medical Publishing, Philadelphia. 2007
Instructional Course Faculty
DePuy Spine Pre-Fellows Cadaver Surgical Course, Las Vegas, NV, Apr 27, 2007.
Medtronic Fellows Cadaver Surgical Course, Las Vegas, NV, Feb 21-22, 2008.
Medtronic Satellite Cadaver Training Lab for surgeons, Bakersfield, CA, Apr 15, 2008.
Research Funding
Analysis of proteases in melanoma spinal metastases, Jul 2001- July 2002 $22000
Use of NIRS (Near-Infrared Spectroscopy) in traumatic brain injury, July 2002- July 2003 $4250
Intramural Lectures & Conferences
1.Steroids and decompressive surgery in spinal cord injury. Univ. of Illinois College of Medicine at Peoria, Neurosurgery Grand Rounds, Jul 28, 2000.
2.Cavernomas of the brain stem and surgical approach to the fourth ventricle. Univ. of Illinois College of Medicine at Peoria, Neurosurgery Pediatric Rounds, Jan 18, 2001.
3.Gamma Knife for Kids. Univ. of Illinois College of Medicine at Peoria, Neurosurgery Pediatric Rounds, Jun 21, 2001.
4.Intracerebral hematoma from aneurysm rupture. Univ. of Illinois College of Medicine at Peoria, Neurosurgery Stroke Conference, Sept 13, 2001.
5.Obesity, low back pain, and the neurosurgeon. Univ. of Illinois College of Medicine at Peoria, Neurosurgery Grand Rounds, Jan 11, 2002.
6.Use of MRI for low back pain. Univ. of Illinois College of Medicine at Peoria, Neurosurgery Grand Rounds, May 2, 2003.
7. Spine: the future of neurosurgery. Univ. of Illinois College of Medicine at Peoria, Neurosurgery Grand Rounds, Jun 11, 2004.
8.Surgical management of osteoporotic compression fractures. Cedars-Sinai Medical Center, Core Curriculum Lecture Series presented by the Institute for Spinal Disorders, Mar 2005.
9.Surgical management of acute spinal cord injury. Cedars-Sinai Medical Center, Core Curriculum Lecture Series presented by the Institute for Spinal Disorders, Apr 13, 2005.
10.Cervical spine clearance. Cedars-Sinai Medical Center, Core Curriculum Lecture Series presented by the Institute for Spinal Disorders, May 4, 2005.
11.Low back pain: how the neurosurgeon can help. Cedars-Sinai Medical Center Institute for Spinal Disorders Community Lecture, Aug 20, 2005.
12.Low back pain: when to see your surgeon. Cedars-Sinai Medical Center Department of Medicine Grand Rounds, Sept. 27, 2005.
13.Evaluation & treatment of the spine trauma patient. Cedars-Sinai Medical Center Department of Surgery Grand Rounds, Oct. 6, 2005.
14.Common lumbar spine pathologies and management. Cedars-Sinai Medical Center Neuroscience Nursing Lecture Program, Dec 8, 2005.
15.Post-operative care after spine surgery. In-service for 6 NW nursing staff, Cedars-Sinai Medical Center, Jan 10, 2006.
16.Post-operative care after spine surgery. In-service for 7 NW nursing staff, Cedars-Sinai Medical Center, Jan 23, 2006.
17.New technologies in spine. Rehabilitation Department. Cedars-Sinai Medical Center, Feb 28, 2006.
18.Posterior foraminotomy for treatment of cervical radiculopahty. Cedars-Sinai Medical Center. Feb 3, 2007.
19.Surgical treatment for ankylosing spondylitis. Orange County SAA meeting, May 5, 2007.
20.Post-operative care after cervical surgery. Neuroscience Nursing Seminar, Jun 5, 2007.
21.Fusion and decompression surgeries in ankylosing spondylitis patients. Cedars-Sinai Medical Center, Mar 24, 2007.
Fellows Trained
1.Anthony Hadden MD, 2005-06
2.Tooraj Gravori MD. 2005-06
3.Edward Rustamzadeh MD. 2005-06
4.Justin Paquette MD, 2005-06
5.Stepan Kasimian MD, 2005-06
6.Eli Baron MD, 2006-07
7.Kevin Ammar MD, 2006-07
8.Ramin Rabbani MD, 2006-07
9.Curt Freudenberger MD, 2007-08
10.Ty Thaiyanathan MD, 2007-08
11.Richard Wupperman MD, 2007-08
Khawar Siddique, MD - Publications |
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Membrane Receptors for Estrogen, Progesterone, and Testosterone in the Rat Brain: Fantasy or Reality
Victor D. Ramirez, Jianbiao Zheng, and khawar M. Siddique
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Anterior Transoral Resection
Eli M. Baron, MD, Khawar Siddique, MD, Brian Perri, DO, Neel Anand, MD, and J. Patrick Johnson, MD
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Acute Odontoid Fractures: Anterior Odontoid Fixation
Brian Perri, DO, Khawar Siddique, MD, Eli M. Baron, MD, and Carl lauryssen, MD
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Complications of the Spine in Ankylosing Spondylitis with a Focus on Deformity Correction
Matthew L. Mundwiler, MD, Khawar Siddique, MD, Jeffery M. Dym, MD, Brian Perri, DO, J. Patrick Johnson, MD, and Michael H. Weisman, MD
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Treatment of Aneurysms with Wires and Electricity: A Historical Overview
Khawar Siddique, MD, Jorger Alvernia, MD, Kenneth Fraser, MD, and Giuseppe Lanzino, MD
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Ganglioglioma Presenting as a Meningioma: Case Report and Review of the Literature
Khawar Siddiqe, MD, Michael Zagardo, MD, Meena Gujrati, MD, and William Olivero, MD
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Modulation of Cystatin C Expression Impairs the Invasive and Tumorigenic Potential of Human Glioblastoma Cells
Santhi D. konduri, Niranjan Yanamandra, Khawar Siddique, Arun Joseph, Dzung H. Dinh, William C. Olivero, Meena Gujrati, Gregory Kouraklis, Amand Swaroop, Athanassios P. Kyritsis and Jasti S. Rao
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Adenovirus-Mediated Expression of Antisense MMP-9 in Glioma Cells Inhibits Tumor Growth and Invasion
Sajani S. Lakka, Mannari Rajan, Christopher Gondi, Niranjan Yanamandra,Nirmala Chandrasekar, Sushma L. Jasti, Yoshiaki Adachi, Khawar Siddique, Meena Gujrati, William Olivero, Dzung H. Dinh, Gregory Kouraklis, Athanassios P. Kyritsis and
Jasti S. Rao
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Modulation of Invasive Properties of Human Glioblastoma Cells Stably Expressing Amino-Terminal Fragment of Urokinase-Type Plasminogen Activator
Sanjeeva Mohanam, Nirmala Chandrasekar, Niranjan Yanamandra, Siddique Khawar, Faiz Mirza, Dzung H. Dinh, William C. Olivero and Jasti S. Rao
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Expression of Antisense uPAR and Antisense uPA from a Bicistronic Adenoviral Construct Inhibits Glioma Cell Invasion, Tumor Growth, and Angiogenesis
Christopher S. Gondi, Sajani S. Lakka, Niranjan Yanamandra, Khawar Siddique, Dzung H. Dinh, William C. Olivero, Meena Gujrati and Jasti S. Rao
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